Wednesday, February 28, 2024

Can Psoriasis Be Detected By Blood Test

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Physical Exam And Medical History Remain The Primary Tools

Psoriasis is an autoimmune disorder primarily affecting the skin. The diagnosis typically involves a physical examination to identify the signs of the disease.

A review of your medical history would also be conducted to assess your symptoms and to rule out any other explanations for your condition. Less commonly, a tissue sample may be obtained to examine skin cells from the affected area with a microscopic.

Unlike some autoimmune disorders, there are no blood tests or imaging studies that can aid in the diagnosis of psoriasis.

Psoriatic Arthritis Blood Test: Anemia

When you have psoriatic arthritis, ongoing inflammation may cause anemia, a decrease in healthy red blood cells that can lead to dizziness, shortness of breath, and exhaustion, says Cadet.

By measuring your blood levels of hemoglobin , your doctor can determine if you have anemia. A normal reading for women is 12 to 16 grams of hemoglobin per deciliter of blood 14 to 18 grams is normal for men, according to the Mayo Clinic.

If blood work reveals anemia, your doctor will give you an exam and other blood tests to find the cause. In people with psoriatic arthritis, treatments that reduce inflammation also help with anemia, explains Cadet.

Frequency of Testing Doctors may order tests to be done several times a year to see if the anemia has worsened or improved.

Additional reporting by .

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Genes Outside The Mhc Region

Association studies in PsA have identified a number of genes outside chromosome 6p including interleukin-1 gene cluster , killer-cell immunoglobulin-like receptors genes , and IL-23R .

IL-1 is up-regulated in the serum and synovium of patients with PsA. An association with the IL-1-889 was first reported in 2004. Subsequently, a study revealed two regions contributing independently to risk of PsA: a region spanned by markers rs3783547, rs3783543, and rs17561 in IL-1A, and a region near the end of IL-1B.

KIRs are one of two groups of receptors on natural killer cells. NK cells are key effector cells in psoriasis and PsA. There is a high degree of polymorphism and complexity in the genes that encode the KIRs. A particular KIR haplotype encodes a distinct set of receptors for an individual’s NK cells. Each NK cell has a combination of inhibitory and activating receptors that interact with certain HLA alleles to influence the immune response. In addition, MICA is also a ligand for an NK receptor . Polymorphism within this gene may also influence susceptibility to PsA through altered interactions with NK cells. Moreover, two publications reported an association between the activating KIR2DS1 receptor and PsA. Interestingly, the association between KIR2DS1 and PsA was only found if the HLA ligand for the corresponding inhibitory receptor was absent.

What Imaging Tests Are Used In The Diagnosis Of Psoriatic Arthritis

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The following imaging tests are used:

  • X-rays. Plain X-rays of the affected joints may show changes that are typically found in psoriatic arthritis.
  • Magnetic resonance imaging . An MRI uses radio waves and strong magnetic fields that give a detailed view of joints, ligaments and tendons in the body.
  • Bone mineral density or BMD test . Psoriatic arthritis and the medications used to treat the condition can cause an increased loss of bone. Your doctor may order this test to know the extent of bone loss. The result indicates your risk of fractures.

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Abnormal Results May Not Be Due To A Disease

A test result outside the normal range of expected lab values does not necessarily mean you have a disease or disorder. Test results can be abnormal for other reasons. If you had a fasting plasma glucose test and you ate something before the test, or were drinking alcohol the night before or taking certain medications, your results could be temporarily outside the normal ranges, but are not evidence of a disease. To avoid such problems, it is best to talk with your doctor before any lab tests about whether you need to make any special preparations before getting your blood drawn, such as fasting the night before.

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Blood And Pathology Tests For Arthritis

Before any tests are done, the doctor will ask you about your symptoms and will often examine you for signs of arthritis or other autoimmune features. Then tests may be done.

Your symptoms and signs on physical examination are more important for making a diagnosis than the results of the tests.

What are blood tests and pathology tests used for?

  • Confirming a diagnosis of arthritis or autoimmune disorder
  • Monitoring disease activity and response to treatment
  • Checking for side effects from medicines

Are all types of arthritis diagnosed by blood tests?

Most forms of arthritis can be diagnosed by blood tests. The doctor may use blood tests to provide support for the diagnosis made on the symptoms and signs, or to help rule out other types of arthritis or conditions that cause similar symptoms. No blood or pathology tests may be required to diagnose some conditions such as osteoarthritis or chronic back pain.

A Positive Test Result May Not Be Positive News

Can a blood test detect cancer?

Some blood tests look for diseases by searching for molecular markers in your blood sample among them the sickle cell anemia test, the HIV test, the hepatitis C test, and the BRCA1 or BRCA2 gene test for breast and ovarian cancer risk. Results are considered positive when the test finds the disease marker DNA, antibody, or protein that it is looking for. In these cases, a positive test result means you may have the disease or disorder or, in the case of infectious diseases, that you may have been exposed to it in the past.

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Diagnosis Involves A Process Of Elimination

To diagnose you with psoriatic arthritis, doctors use your medical history, a physical examination, and X-rays or other imaging studies.

Blood tests and synovial fluid analyses may help rule out other types of arthritis, such as gout, rheumatoid arthritis , or osteoarthritis .

Psoriatic arthritis is a type of inflammatory arthritis that belongs to a group of conditions known as spondyloarthropathies. It is a progressive autoimmune disease that affects the joints and skin.

If it’s not adequately treated, it may lead to permanent joint damage and disability.

Psoriatic arthritis can be well managed with certain medications. But treatments for other types of arthritis aren’t effective against psoriatic arthritis. That makes getting an accurate diagnosis extremely important.

How Is It Diagnosed

Your doctor will diagnose psoriatic arthritis from your symptoms and a physical examination. Your skin will be examined for signs of psoriasis, if you have not been diagnosed with this already. There is no specific test for psoriatic arthritis. However your doctor may order blood tests for inflammation, such as the erythrocyte sedimentation rate test. Blood tests may also help to rule out other types of arthritis. If your doctor suspects you have psoriatic arthritis you should be referred to a rheumatologist, a doctor who specialises in arthritis.

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Psoriatic Arthritis Blood Test: Anti

Blood tests that look for the presence of anti-cylic citrullinated peptide antibodies , which are inflammatory, are commonly used to diagnose rheumatoid arthritis, but anti-CCPs can also indicate psoriatic arthritis.

Roughly 8 to 16 percent of people with psoriatic arthritis will test positive for anti-CCPs, says Rubenstein.

Frequency of Testing Some physicians will perform the test yearly, says Cadet.

Psoriatic Arthritis Skin And Blood Tests: Tuberculosis Test

Psoriatic arthritis

Tuberculosis is a bacterial infection that typically affects the lungs but can also reach bones, joints, and kidneys. Symptoms include fever, night sweats, chills, coughing, weight loss, and fatigue.

People with psoriatic arthritis must have a negative TB test before they can take biologic medications, which are protein-based drugs given by injection or infusion. By suppressing the immune system, these medications may reactivate latent tuberculosis.

There are two kinds of TB tests: a skin test and a blood test. The skin test involves injecting a small amount of a protein called tuberculin into the skin of the lower arm, then checking the area around 48 to 72 hours later to see if there has been a reaction. The result depends on the size of the raised, hard area or swelling, according to the Centers for Disease Control and Prevention.

A TB blood test assesses whether the body has launched an immune response to the presence of M. tuberculosis bacteria. The test is done in a lab after a blood sample is drawn.

Frequency of Testing Doctors order a TB test before prescribing biologics and may repeat testing annually as long as a patient is taking the medication, says Cadet. She adds, Any patient who exhibits symptoms or has been exposed to TB should have an immediate TB test.

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Getting Tested For Psoriatic Arthritis

Testing for psoriatic arthritis is ordered by your doctor or a specialist, such as a rheumatologist, a doctor who specializes in joint diseases, or a dermatologist, a doctor whose specialty is treating the skin. Blood and urine specimens used in testing can be provided in a doctors office or laboratory.

Synovial fluid analysis involves collecting a small amount of joint fluid using a process called arthrocentesis. During this procedure, a needle is used to withdraw fluid from the space around a joint. It is usually done at a doctors office.

Some diagnostic imaging tests, like x-rays, may be done in a doctors office. Others may need to be performed at an imaging center or hospital radiology department.

What To Expect At The Doctors Office

You may be seeing various health care providers during your journey to figure out whats causing your symptoms. Its common for people to see their internist/general practitioner, a dermatologist to treat their psoriasis, or other types of doctors to manage specific areas that are causing pain, such as a podiatrist to treat foot pain. However, if you or any of the health care providers you are currently seeing suspect it could be psoriatic arthritis, ask for a referral to a rheumatologist. These doctors specialize in arthritis and have the training to determine whether your joint symptoms are due to PsA or could be something else.

Psoriatic arthritis can be challenging to diagnose for a number of reasons, including:

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Psoriatic Arthritis Imaging Test: X

X-rays, which use low-dose radiation to produce images of the inside of the body, can help your doctor make a psoriatic arthritis diagnosis and monitor progression of the autoimmune condition.

X-rays allow the doctor to see changes to the bone, says Elyse Rubenstein, MD, a rheumatologist in Santa Monica, California. In people with psoriatic arthritis, X-rays may show bone erosion, new bone formation, bone fusion, or a phenomenon called pencil in a cup, in which the ends of the bone have been eroded to a pencillike point. Any of these changes indicate that the disease is getting worse, Dr. Rubenstein says.

Frequency of Testing A doctor may take an initial X-ray to help diagnose psoriatic arthritis and rule out other forms of arthritis, such as rheumatoid arthritis, which have different patterns of joint involvement, says Rubenstein.

After that, how often you have X-rays depends on your physician and the state of your disease. Some doctors take X-rays just once a year for routine monitoring, while others may take them only when a patients condition changes.

Tests To Diagnose Psoriatic Arthritis

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Blood Tests

These tests can help confirm psoriatic arthritis and rule out other conditions, like rheumatoid arthritis.

  • Erythrocyte sedimentation rate : Gives a rough idea of how much inflammation is in your body, which could be caused by psoriatic arthritis. But higher levels can come from other autoimmune diseases, an infection, a tumor, liver disease, or pregnancy, too.
  • Rheumatoid factor and anti-CCP antibody: These tests can rule out rheumatoid arthritis. People with that condition may have higher levels of these in their blood.
  • HLA-B27: More than half of people who have psoriatic arthritis with spine inflammation will have this genetic marker. You can get tested to find out if you do.
  • Iron tests: People with psoriatic arthritis may have mild anemia, or not enough healthy red blood cells.


These can show cartilage changes or bone and joint damage that suggests arthritis in your spine, hands, or feet. Psoriatic arthritis usually looks different on X-rays than rheumatoid arthritis does.

Bone Density Scan

Because psoriatic arthritis may lead to bone loss, your doctor may want to measure your bone strength. You could be at risk for osteoporosis and fractures.

Joint Fluid Test

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Why Do I Fill In Questionnaires At Each Appointment

Psoriasis can be associated with psoriatic arthritis, anxiety and depression and may have an impact on daily life. We therefore assess each of these areas using a questionnaire. We will ask you to fill in a DLQI, PEST and HADS questionnaire at each appointment in order to assist with monitoring your response to treatment. At times it will seem repetitive, but the HADS and PEST scores only need to be performed every six months.


This questionnaire enquires about how your psoriasis affects the clothes you wear, activities of daily living, work and relationships. It is scored out of 30. A score above 10 indicates a major life impact.


This questionnaire assesses whether or not you have joint pain and swelling which could be psoriatic arthritis. It also asks about nail psoriasis which can be associated with psoriatic arthritis. A positive score does not mean you have psoriatic arthritis, but we may refer to a rheumatologist for an assessment.


This questionnaire screens for anxiety and depression. A score above eight in either of the anxiety or depression questions indicates a possible anxiety or depressive disorder and a score above 11 is highly suggestive of anxiety or depression. If you have high anxiety or depression scores we may suggest you see your GP for advice or refer you to our psychodermatology service.

What Will Happen To Me

With the right treatment, most people with psoriatic arthritis can lead full and active lives. However the course of psoriatic arthritis is variable and no two cases are the same. Many people find their symptoms worsen at times and then settle down for a period of time. About one in 20 people with psoriatic arthritis will develop a more severe, destructive form which can cause deformity to the joints in the hands and/or feet. Most people with psoriatic arthritis will need some ongoing treatment to control their symptoms and prevent damage to the joints. This is usually managed by a rheumatologist.

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Symptoms And Family History

40 percent of people with psoriasis or PsA had a family member with either psoriasis or PsA.

In the study, those with a family history of PsA had a higher risk for developing deformities from PsA, but a lower risk for developing plaque psoriasis, the red, scaly skin patches that are a common symptom of psoriasis.

Researchers are only now beginning to decipher the specific genes associated with PsA. The main challenge is distinguishing genes responsible for psoriasis from those responsible for PsA.

Identifying the genes that lead to PsA may pave the way toward developing gene therapy for treating PsA.

A Genetic Screening Test For Psa

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The goal of genetic screening is to identify subjects for preventive or early treatment or extended surveillance prior to the onset of symptoms. Therefore, the sensitivity of the test should be high and similarly, high specificity is desired to increase the efficacy of the screening and minimize the number of subjects who will be treated unnecessarily.

Current PsA screening techniques identify symptomatic patients after the onset of inflammatory arthritis. Identifying PsA in an earlier or a pre-clinical stage will allow treatment to be initiated at a time when intervention has a greater likelihood of succeeding. Early screening combined with tailored treatment will help preventing disease progression and irreversible slow joint destruction. The need for early screening and medical intervention for PsA is underscored by the fact that PsA becomes more severe when left not properly treated or untreated, leaving patients with significant joint damage, functional impairment, and reduced quality of life.

Therefore, a genetic screening test has been recently developed in order to identify patients at a high risk for developing PsA prior to the onset of arthritic symptoms. The genetic screening test is most appropriate for individuals with psoriasis who have not yet developed PsA. It is also useful to assess the risk for individuals who have a family history of psoriasis or PsA.

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