Complications Of Low Platelet Count
Low platelet count, left untreated, can give rise to a multitude of complications, which is why it is suggested that it get resolved as soon as possible.
In some cases however it might not get resolved for lack of resources or other issues, and in this case, there can be several complications.
Cuts and wounds may not stop bleeding and one may suffer severe blood loss and the most minor injuries can become life-threatening.
Excessive bleeding from injuries or even without injuries can increase the risk for anemia, especially in women with low platelet count, menstruation can become a huge risk factor.
The tendency to get bruises may get so bad that one may have to stay away from ones favorite activities.
There is a tendency to get tiredness with the most minimal work and this interferes with peoples daily activities. In addition, the anemia from blood loss contributes further to fatigue and weakness.
In severe cases, the person may even experience internal bleeding which can lead to organ failure eventually, if unchecked. If this bleeding happens in the brain it can be fatal instantly.
The risk of getting a serious infection increases drastically in those with low platelet counts.
Lastly, as would be expected in someone suffering from a blood-related disorder, life expectancy can be greatly reduced.
Cardiovascular Diseases And Stress
In the late 1990s, two studies investigated the effect of hostility as a chronic mental stress condition on platelet reactivity in patients with preexisting cardiovascular diseases .2). Plasma -TG levels and GPIIb/IIIa receptor activation were measured. The investigations observed that hostility was significantly related to higher -TG reactivity and increased platelet activation index markers, such as GPIIb/IIIa activation and fibrinogen binding.
- What are my treatment options? Which do you recommend?
- Do these treatments have side effects? What can I do about them?
- How will we know if the treatment is working?
- When will I start to feel better?
- What do you expect for my case?
- Does this condition put me at risk for anything else?
- Do I need to see a specialist?
Side Effects And Risks
Stelara and Humira both contain different drugs. Therefore, the medications can cause very different side effects. Below are examples of these side effects.
More common side effects
These lists contain examples of more common side effects that can occur with Stelara, with Humira, or with both drugs .
- Can occur with Stelara:
- redness, pain, or swelling at your injection site
Serious side effects
These lists contain examples of serious side effects that can occur with Stelara, with Humira, or with both drugs .
- Can occur with Stelara:
- posterior reversible encephalopathy syndrome
- lung problems that are caused by inflammation in your lungs
- possible increased risk of cancer
- severe allergic reaction
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Ask Questions About Your Lab Results
It can be alarming to see a word like âthrombocytopeniaâ or a low number compared with the baseline on your lab results.
For most patients, having mild-to-moderate low platelets wonât change your pregnancy care or birth plan much, if at all. Moore, despite the changes to her plan, that her healthy baby boy arrived on his due date in late February.
However, it is important to talk with your doctor about your risks for complications related to low platelets. If your lab results indicate low platelets, follow Mooreâs lead ask your provider to explain what that means for you. Weâre hear to help you make informed decisions and have a healthier, safer pregnancy and delivery.
To visit with an Ob/Gyn about low platelets in pregnancy, call orrequest an appointment online.
If I Take Stelara For A Long Time Will I Have Withdrawal Symptoms When I Stop Using It
Its possible that your condition may return or worsen if you stop taking Stelara. This can lead to symptoms that may be confused with withdrawal symptoms.
Dont stop taking Stelara unless your doctor recommends that you stop treatment. Once you stop taking Stelara, your doctor will monitor you closely to determine if you can safely remain off the medication.
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Thrombocytopenia Causes In Adults
Thrombocytopenia or low platelet count can be a result of a variety of reasons. The factors causing the blood disorder can be generally divided into three classes. Thrombocytopenia may be due to increase in the destruction or consumption of platelets, increased splenic sequestration , or .
An increase in the number of platelets destroyed or consumed can be seen in a number of medical conditions. These disorders may either be immune related or non-immune related factors. There are also drug-related factors that result to low platelet count by triggering reactions on immune functions to work against normal blood platelets. This is called drug-induced thrombocytopenia.
Decreased production of platelets is usually a problem associated with bone marrow functionality. In some conditions, the production of red blood cells and white blood cells may as well be affected. Common thrombocytopenia causes in adults include: Sulphonamide antibiotics, Idiopathic thrombocytopenic purpura , Thrombotic thrombocytopenic purpura , Hemolytic Uremic Syndrome , Splenic sequestration, Plastic anemia, Cancer, Immune thrombocytopenia, medication and bacterial infection in the blood.
What Causes Low Platelet Count
Low platelet count can be caused by multiple factors, and in many cases, it is easily reversed.
Changing your medications or diet, or addressing the health condition behind the lowered count may be accomplished rather quickly.
For cases where platelet production is the focus of care, medicines can boost counts in a hurry as well. Therefore, mitigating the risk of thrombocytopenia is quite possible when the appropriate diagnosis is made and action taken immediately.
The main causes of thrombocytopenia are:
- Insufficient production of platelets by the bone marrow
- Rapid destruction or overuse of platelets
- Excess, or trapped, platelets in the spleen
Some other causes of low platelet counts include:
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Side Effects Requiring Immediate Medical Attention
Along with its needed effects, acitretin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking acitretin:
- vision changes
- weakness in the arms, hands, legs, or feet
Get emergency help immediately if any of the following symptoms of overdose occur while taking acitretin:
Symptoms of overdose
- feeling of constant movement of self or surroundings
- sensation of spinning
Cell Surface Marker Expression Screening In Whole Blood
A cell surface antigen screening was performed using the LegendScreen from Biolegend . Whole blood was drawn from five psoriasis patients and five sex- and age-matched controls. Erythrocyte lysis was performed for 5 min at 4°C on a roller shaker using 154 mM NH4Cl, 10 mM KHCO3, 0.1 mM EDTA pH 8 , pH of buffer adjusted to 7.3 and sterile filtered . After a short spin, FC block was performed and the cells were stained with anti-CD3, -CD15, and -CD19, excluding dead cells using Zombie Yellow. Subsequently, the stained cells were aliquoted into 96 well-plates, each containing a PE-labeled antibody directed against one of 332 surface antigens, and 10 isotype controls in PE. The following washing and further steps were performed using the manufacturer’s instructions, except that one kit was divided for the measurement of four donors. FACS measurements were performed using a MACSQuant analyzer and subsequently FlowJo V10 was used to analyze the data. The gating strategy is depicted in Figure S1 and T cells, PMNs, and B cells gated according to the Abs in the master mix. Monocytes were gated by granularity and size but not additionally verified with CD14 staining. However, in the well-containing anti-CD14-PE Abs, all gated events were CD14-positive.
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Fatal Thrombotic Thrombocytopenic Purpura In A Psoriasis Patient Treated With Ustekinumab And Methotrexate
Laure Philippe1, Julio Badie2, Jean Pierre Faller2, Élise Krattinger3, Eric Deconinck1 and François Aubin4
1Department of Hematology, University Hospital, Besançon, 2Department of Réanimation and Internal Medicine, General Hospital, 3Department of Cytopathology, General Hospital, Belfort, and 4Department Dermatology, University of France Comté, EA3181, and University Hospital,3 Bd Fleming, 25030 Besançon, France. E-mail:
Accepted Oct 16, 2014 Epub ahead of print Oct 17, 2014
Biological therapies are specially designed to block specific molecular steps in the pathogenesis of psoriasis and have been demonstrated to be an effective treatment in moderate to severe chronic plaque psoriasis. One of these drugs, efalizumab, has been previously reported as a potential precipitating factor for TTP . More recently, ustekinumab, a monoclonal antibody, which binds both interleukin -12 and IL23, was also considered as a potential secondary cause of TPP in a case report . Here we report a new case of TTP in association with ustekinumab used for psoriasis treatment.
In this report, we present a second case of TTP occurring in a psoriasis patient treated with ustekinumab . This monoclonal antibody binds to the p40 subunit of IL-12 and IL-23, key cytokines in the pathogenesis of psoriasis . Studies have not only shown clinical benefit in the management of psoriasis, but also a lack of long-term toxicity .
The authors declare no conflict of interest.
Drug Forms And Strengths
Stelara comes as a liquid solution that contains the active drug ustekinumab.
Its available as:
- a single-dose, prefilled syringe that holds 0.5 mL of solution and contains 45 mg of ustekinumab
- a single-dose, prefilled syringe that holds 1 mL of solution and contains 90 mg of ustekinumab
- a single-dose vial that holds 0.5 mL of solution and contains 45 mg of ustekinumab
Stelara is given as a subcutaneous injection. It can be given in your upper arms, thighs, belly, or buttocks.
Your healthcare professional may give you Stelara injections at a medical clinic. They may also show you how to self-inject Stelara at home.
Note: Stelara also comes in a vial that contains 130 mg of ustekinumab. This vial is used for a one-time intravenous infusion of Stelara. Its used to give the first dose of the drug to people with Crohns disease or ulcerative colitis. This one-time infusion is called a loading dose or an induction dose. This IV infusion will take place over at least 1 hour. Each dose of Stelara after the IV infusion is given as a subcutaneous injection.
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What Vaccines Can I Get During Stelara Treatment
Stelara makes your immune system less able to function. Certain vaccines are made from weakened forms of a virus. Because your immune system cant fight off the virus very well, you shouldnt get live vaccines during Stelara treatment. Doing so can put you at risk for developing the infection that the vaccine is meant to prevent.
Your doctor may recommend that you have all of the vaccines you need before you start Stelara treatment. This includes both live and non-live vaccines, with the exception of the Bacillus Calmette-Guérin vaccine.
The BCG vaccine is meant to prevent tuberculosis . Its more commonly given to people who live outside of the United States. You shouldnt start taking Stelara for at least 1 year after youve received a BCG vaccine.
If you receive any non-live vaccines while youre taking Stelara, its possible that your immune system wont have the right response to the vaccine. This means that the vaccine might not be able to prevent the infection that its meant to prevent.
Talk with your doctor to make sure you are up to date on all of your vaccinations before you start using Stelara.
Recovery Of Platelet Parameters In The Condition With And Without Chronic Mental Stress
We performed an additional analysis of platelet function recovery for the condition CS+ and CS- outside the mixed linear model reported above. Observed values were compared by analyzing the difference between T1 and T3 in the condition CS+ and CS-. Platelet CD62P showed impaired recovery i.e. a prolonged activation in the CS+ condition CS+: mean 0.85 CS-: mean 1.52 , T-Test, p=0.023). The recovery of the other platelet activation markers CD63 , PAC-1 and CD45highCD42b+ was not significantly altered in CS+ condition compared to CS-.
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Platelet Activation Due To Mental Stress In Healthy Individuals And Elderly Persons
Stress induces hypothalamic-pituitary-adrenal axis hyperdrive and leads to a functional alteration of the central sympathetic and serotonergic system, possibly via neurotransmission influenced by a corticotrophin-releasing factor. This HPA axis overactivity is sustained by activation of the inflammatory response system through mental stress.
The effect of mental stress tasks â mental arithmetic or cold pressor test â on platelet bioactivity PF-4 and -TG has been assessed in healthy young men. A significant influence of stress tasks, resulting in an increase in PF-4 and -TG, was observed.
Aschbacher et al conducted four different studies on platelet reactivity in elderly persons. In dementia caregivers, which is an established paradigm of chronic mental stress, the effect of additional acute mental stress in combination with depressive and anxious symptoms or hormone replacement therapy was investigated in a cross-sectional design. Two longitudinal studies were also performed to assess the effect of acute mental stress in an elderly population without caregiving strain and in dementia caregivers in combination with persistent depressive symptoms.
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Dosage For Plaque Psoriasis
Stelara is approved to treat plaque psoriasis in both adults and children ages 6 years and older. The typical dosage for adults is described here.
Stelara is given as one subcutaneous injection on each of the following days:
- your first dose is given on day 1
- your second dose is given 4 weeks later
- your third dose is given 12 weeks after your second dose
- the rest of your doses are given every 12 weeks
The usual dosage of Stelara for plaque psoriasis is based on your body weight and age. In adults with plaque psoriasis, the typical dosage of Stelara for each injection is as follows:
- for adults who weigh 100 kilograms or less, their usual dosage is 45 mg
- for adults who weigh more than 100 kilograms, their usual dosage is 90 mg
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Key Points About Psoriatic Arthritis
- Psoriatic arthritis is a form of arthritis with a skin rash.
- Psoriasis is a chronic skin and nail disease. It causes red, scaly rashes and thick, pitted fingernails. The rash may come before or after the arthritis symptoms.
- Psoriatic arthritis causes inflamed, swollen, and painful joints. It happens most often in the fingers and toes. It can lead to deformed joints.
- Treatment may include medicines, heat and cold, splints, exercise, physical therapy, and surgery.
What Does Low Platelet Count Mean Definitions And Meaning Of Low Platelets
Low platelet count is medically known as Thrombocytopenia.
It causes fatigue, among other things, which makes you feel like not doing anything.
Symptoms and signs of thrombocytopenia may also be bleeding and not clotting in time after getting hurt.
Thrombocytopenia or low platelet count is when there is lower than a normal number of platelets in the blood.
Thrombocytopenia can be an inherited or acquired condition and can occur in situations such as when there is the use of certain drugs.
The Causes of thrombocytopenia can be divided into three broad groups depending on how it happens:
· Diminished production
· Increased destruction
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How Is Psoriatic Arthritis Treated
Treatment will depend on your symptoms, age, and general health. It will also depend on the severity of your condition.
Boththe skin condition and the joint inflammation are treated. Early diagnosis andtreatment helps prevent joint damage. Some medicines used to treat psoriatic arthritisinclude:
- Nonsteroidal anti-inflammatory medicines to ease symptoms
- Corticosteroids for inflammation
- Immunosuppressive medicines such as methotrexate to reduce inflammation if NSAIDs don’t work
- Biologic medicines to ease inflammation
- Vitamins and minerals such as calcium and vitamin D to slow bone deformation
Other treatment may include:
Imiquimod Model Of Psoriatic Skin Inflammation
Prior to and after daily topical application of 5% imiquimod cream to the ears of anesthetized mice ear thickness was measured with a manual caliper on d0 to d5. For flow cytometry analysis, retro-orbital blood samples were collected on d0 and d5, diluted in TBS containing 5 U/ml Heparin and subsequently PBS and an aliquot stained using appropriate antibodies . Murine blood PMNs were detected by CD11b + Ly6Cint cells, thereby avoiding issues with antibody masking by anti-Ly6G . The same applied to murine blood platelets, which were depleted with anti-CD42b mAb, but detected by flow cytometry with anti-CD41 mAbs. Full thickness ear skin was excised on d5, fixed in 10% formalin and paraffin-embedded. Skin cross-sections were stained by H & E according to standard procedures. At least 10 epidermal thickness measurements per mouse were averaged.
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Leukemia Bruising On Legs
Although bruises from leukaemia are very similar to ordinary bruises, there are a few things you can look out for to help spot the difference: They occur in unusual places In cases of leukaemia, quite often bruises will appear in places that you wouldnt normally expect, especially the back, legs, and hands.
Very Low Platelet Count
Gender. Sex-related differences in platelet count were described for the first time in 1977 in a study that analyzed 868 blood donors. The mean platelet count was higher in women than men in all age classes, although the differences were small and tended to diminish after menopause. Subsequent studies confirmed that females have a slightly higher platelet count. 7, 8 .
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