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Vitamin D Deficiency Causes Psoriasis

Vitamin D Treatments Target Psoriasis

Role of Vitamin D in Psoriasis healing

Study Helps Explain How Ultraviolet Light Therapy and Vitamin D Creams Treat Psoriasis

May 12, 2011 — Ultraviolet light therapy and vitamin D creams are widely prescribed treatments for psoriasis, and now a new study may help explain why they work for so many patients.

Researchers say the vitamin D-based treatments increase the binding of a peptide called cathelicidin to DNA, which, in turn, inhibits the inflammatory response that triggers psoriasis.

The finding may one day lead to better treatments for the painful skin condition that specifically target cathelicidin, study researcher Jurgen Schauber, MD, of Ludwig-Maximillian University in Munich, Germany, tells WebMD.

âWe were able to identify a novel, pro-inflammatory signaling pathway which helps us understand why treatments work,â he says.

Thiamine Deficiency Causes Lactic Acidosis

A report presents a case of 56 years old man with lactic acidosis whose symptoms rapidly improved after intravenous administration of thiamine.

Patient consumed the alcohol regularly and shortly before the hospitalization lost about 5 kg.

In acute deficiency, pyruvate accumulates and is metabolized to lactate, and chronic deficiency may cause polyneuropathy and Wernicke encephalopathy. Classic symptoms include mental status change, ophthalmoplegia, and ataxia but are present in only a few patients. Critically ill patients are prone to thiamine deficiency because of preexistent malnutrition, increased consumption in high-carbohydrate nutrition, and accelerated clearance in renal replacement.Thiamine deficiency may become clinically evident in any type of malnutrition that outlasts thiamine body stores , including alcoholism, bariatric surgery, or hyperemesis gravidarum, and results in high morbidity and mortality if untreated.

As you can see the body has stores of thiamine only for about 3 weeks so consider this if somebody tells you how great it is to have 1 months water fast. It is similar also with some other nutrients which get rapidly depleted so long-term water fast may cause more damage than good.

As you see even administration of sodium bicarbonate didnt decrease the lactate levels even though the overall blood pH improved.

As you see, if the doctors know what is the problem body may recover pretty fast.

Effects Of Vitamin D On The Cutaneous Immune System

Psoriasis pathogenesis implicates the innate and adaptive segments of the immune system. In particular, it is centrally controlled by T cells, in which an important role is played by T-helper 1, Th17 and Th22, interplaying with numerous cell types via different cytokines, including tumour-necrosis factor- , IL-6 and IL-17 . The activity of these cells is modulated by specific T lymphocytes, named regulatory T cells . Regulatory T cells are able to inhibit the immunological response and to preserve the cutaneous immunological homeostasis, preventing autoimmune response against self-antigens .

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Scam Supplements Like Alkalizing Ph Drops For Psoriasis

Actually, you are buying just an expensive mineral water and hope it will cure your psoriasis. What causes low blood pH besides the deficiency of essential vitamins and minerals as mentioned above in this post? Of course that its the endotoxins and inflammatory processes.

There is so much misinformation about the all pH thing: take mineral supplements, drink lemon water, dont eat acidic foods, and mostly buy those overpriced pH boosting supplements.

Selling the trace minerals and alkalizing solutions is a great business idea. But check the bottles of those products and you will see that there is actually nothing meaningful stated on many of them.

You wont find out how much minerals is in them. And if there is a detailed information about the mineral content you will find out that you are going to buy like 5 grams of dissolved magnesium for 20 dollars.

Now just do some math, if there is about 200 servings then you will get 25 mg of elemental magnesium in one serving. Many people put that one serving to 1 liter of water and feel good with themselves because they are drinking the alkalizing water.

25 mg/L of magnesium is the amount you can find in many bottled mineral waters on the market or even in the tap water.

And what do you think, why it doesnt work? Why those pH boosters do not help to increase the pH?

Because inflammation is the common cause of low pH

Everything is nothing compared to the effects of endotoxins on blood pH levels.

The Effect Of Vitamin D Supplementation On Psoriasis Severity

The 25+ best Vitamin d cream ideas on Pinterest
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
First Posted : November 7, 2017Last Update Posted : October 8, 2020
  • Study Details
Condition or disease
Drug: 25-Hydroxyvitamin DDrug: Placebo oral capsule Not Applicable

Studies have indicated an association between lower levels of vitamin D and increased risk of psoriasis. This study investigate if vitamin D supplementation can reduce the severity of the skin disease as measured by Psoriasis Area Severity Index , as well as positively influence the cardiometabolic profile and skin microbiota of persons with psoriasis through a winter season.

Consenting participants will be randomized to high dose vitamin D versus placebo for four months. The participants will be recruited based on their 25-hydroxyvitamin D D)-measurements in the 7th survey in the Tromsø study where 21.083 subjects attended.

  • Psoriasis Area Severity Index score The difference in change between the vitamin D and placebo group in psoriasis severity measured by PASI score. Score range from 0-72, where a higher value indicates a more severe disease.
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    Why Dermatologists Prescribe Synthetic Vitamin D To Treat Psoriasis

    Synthetic vitamin D can:

    • Slow rapidly growing skin cells

    • Flatten thick psoriasis

    • Synthetic vitamin D is considered safe for most patients, including children

    • It clears psoriasis in some patients, including patients who have scalp psoriasis

    • Most people notice an improvement after using it for two weeks

    • If a patient needs stronger medicine, synthetic vitamin D can be safely combined with a strong corticosteroid

    Studies show that using both tends to be more effective than using either medication alone.

    • Using both synthetic vitamin D and a corticosteroid can also reduce the possible side effects that come with using a strong corticosteroid

    • The combination can be used for much longer than a strong corticosteroid alone

    Some Conditions Can Interfere With Vitamin B12 Absorption

    Unfortunately, even supplementing with vitamin B12 orvitamin B12-rich foods doesnt always ensure that someone wont be deficient inthe vitamin. Some auto-immune conditionsand psoriasis is an auto-immuneconditioninterfere with the bodys ability to absorb vitamin B12. In suchcases, one may have to take vitamin B12 injections.

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    How To Get More Vitamin D:

    There are several ways to increase vitamin D levels in the body. The easiest way is to expose the skin to direct sunlight, which consists of both UVA and UVB rays. UVA exposure can increase the risk of skin cancer, so psoriatic patients should consult a doctor to see how much sun exposure is necessary. Vitamin D supplements are also beneficial ways to raise vitamin D levels. According to the Institute of Medicine, an upper limit of 4,000 IU per day may prevent psoriatic side effects. Lastly, there are are some food sources of vitamin D, but try to steer clear of fortified foods. Its best to focus on more natural foods that contain vitamin D.

    Risks And Shortcomings Of Vitamin D

    Psoriasis cured by vitamin D supplementation

    Vitamin D can help many people with psoriasis. Still, its often not an effective long-term treatment on its own. Some people will need topical medications with other active ingredients, including corticosteroids. Vitamin D also wont work for everyone, regardless of what form its taken in.

    The biggest risk of taking vitamin D is taking too much. Vitamin D in moderation is good for you, but taking too much can hurt you. It causes a condition called hypervitaminosis D, or vitamin D toxicity. This condition can cause a buildup of too much calcium in the blood, which can cause frequent urination, weakness, and eventually kidney problems. Its typically only caused by excessive doses of vitamin D supplements. It almost never occurs from diet or sunlight exposure.

    As long as you take vitamin D in moderation, you should be able to avoid vitamin D toxicity. Your risk increases, though, if you have liver or kidney conditions already.

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    Other Vitamins And Supplements For Psoriasis

    There is not much evidence to suggest that vitamins or dietary supplements help reduce symptoms of psoriasis.

    However, oily fish are a good source of vitamin D, and some people with psoriasis believe that omega-3 fatty acid supplements help ease their psoriasis.

    Omega-3 fatty acids may reduce inflammation, and psoriasis is an inflammatory disease.

    However, there are not enough long-term clinical trials to show whether these supplements are effective for treating psoriasis.

    Vitamin D And Keratinocyte Apoptosis

    The effect of vitamin D on the keratinocyte apoptosis is dose dependent, similar to its effect on cellular proliferation. At physiological concentrations, vitamin D prevents apoptosis triggered by various proapoptotic stimuli like ceramide, UV radiation, TNF-, etc., while at high concentrations it induces apoptosis in keratinocytes . The antiapoptotic or cytoprotective effect of vitamin D is shown to be mediated by sphinosine-1-phosphate. Other mechanisms are also reported to be responsible for the antiapoptotic effect of vitamin D like the activation of MEK/ERK and PI3K/Akt signaling pathways, and the increased ratio of antiapoptotic protein to proapoptotic protein .

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    Psoriasis And Acidic Blood: The Cause Is Deficiency Of B Vitamins

    Lactic acidosis is often caused by biotin or thiamine deficiency. The role of B-vitamins is still underrated by most people including those with psoriasis. We have a huge promotion ofmagnesium, zinc, vitamin C, but where are the B-complex vitamins? I think that generally the most important thing in healing of psoriasis is proper intake of B-vitamins.

    If you want to get all of the B-vitamins even those who are no longer considered as vitamins you should take brewers yeast or what is even better beef liver.

    Even though our bodies are able to synthesize some chemicals that does not mean it is not important or inevitable to provide them in the food we eat.

    Not just that we need the minerals and other vitamins to make some very important non-essential chemicals but everybody is unique and we have various genetic variations which may prevent us from producing or processing some important molecules efficiently and in sufficient amounts.

    Of course, B1 and B7 deficiencies are not the only possible causes of lactic acidosis but they are well documented. Overall nutrition is important and elimination of unnecessary toxins is advised.

    Psoriasis Causes: Just A Toxicity And Deficiency

    Vitamin D for Psoriasis #naturalremediesforplaquepsoriasis ...

    and deficiency causes the toxicity, toxicity causes the deficiency and again the deficiency causes the toxicity so psoriasis is just the toxicity . No matter if its scalp psoriasis, nail psoriasis, arthritis, fibromyalgia, cancer, depression, diabetes or some other health condition. Every illness roots from these two causes. Although I am not sure that the plaques are there directly because its the way how the body tries to get rid of the toxins it actually doesnt matter if it is so.

    We should take a look at the whole psoriasis problem more deeper but from the different angle than we usually do. I am not a fan of common sense in medicine that we should shut off the immune system with drugs so our body cant fight with something and be happy that our skin symptoms will disappear. Most people which go off the drugs after they stopped working or cant tolerate them because of the other effects get their psoriasis often even worse. I am not surprised by that mostly if it would be true that the bacteria have a big deal in psoriasis development. If you would suppress the immune system for years to the point that cant handle effectively any infections then you shouldnt be surprised that eventually when you go off the immunosuppressants the spread bacterial infection will manifest as more psoriasis plaques.

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    Start Your Day With Fortified Cereal

    Fortified cereal is another easy way to get your daily fill of vitamin D. Look for a low-calorie fortified hot or cold cereal, and read the package label to determine how much vitamin D you will get and whats considered a serving size.

    Bonus points if you top your bowl of cereal with fortified milk and pair it with a glass of fortified OJ.

    Let The Sun Shine: Is Light Therapy Legit For Treating Psoriasis

    Light therapy uses the power of ultraviolet light to help reduce inflammation and slow skin cell production in psoriasis patients. During a phototherapy sesh, the affected area is exposed to artificial UVB light which penetrates the skin to help ease symptoms.

    With light therapy, consistency is key. Its important to follow a regular treatment schedule to up your chances of seeing results. Just note, you may also be upping your risk of skin cancer.

    Research has shown that ultraviolet light can significantly improve psoriasis symptoms. But some studies have also found this is likely thanks to more than just vitamin D. Bottom line: More research is needed to fully determine why light therapy is so darn effective in treating psoriasis and other skin conditions.

    There can be a dark side to vitamin D. While adding a bit of D to your day may help ease psoriasis symptoms, its not without potential side effects.

    A 2016 study found that using vitamin D topicals can cause skin to become:

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    Vitamin D Insufficiency Prevalent Among Psoriatic Arthritis Suffers

    New research reports a high prevalence of vitamin D insufficiency and deficiency among patients with psoriatic arthritis. Seasonal variation in vitamin D levels was not observed in patients in southern or northern locations. The findings also show no association between disease activity and vitamin D level.

    New research reports a high prevalence of vitamin D insufficiency and deficiency among patients with psoriatic arthritis. Seasonal variation in vitamin D levels was not observed in patients in southern or northern locations. The findings published in Arthritis Care & Research, a journal of the American College of Rheumatology , also show no association between disease activity and vitamin D level.

    Psoriasis is a common chronic skin disorder, likely caused by an autoimmune response, and is characterized by red scaly patches on the surface of the skin. When accompanied by inflammatory arthritis the condition is known as psoriatic arthritis — a disease gaining public attention with the recent diagnosis of professional golfer, Phil Mickelson. Studies suggest that psoriasis occurs in up to 3% of the world population and roughly one third of these patients have PsA with prevalence estimates ranging from 6% to 42%.

    Story Source:

    Talk To Your Doctor About Vitamin D Supplements

    DID IT WORK?! Vitamin D Deficiency Update ( Seborrheic Dermatitis, Gluten Free)

    The NPF says the evidence that vitamin D supplements can ease psoriasis symptoms is weak, and that the best way to get more vitamin D is through food. But if you find you cant bump up your intake of vitamin Drich foods, or if you have psoriatic arthritis, ask your doctor if taking a vitamin D supplement might make sense.

    Just be sure not to turn a vitamin deficiency into vitamin overload. Excessive amounts of vitamin D can affect your blood pressure, cause muscle weakness, and lead to gastrointestinal problems.

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    How Vitamin D Deficiency Contributes To Psoriasis

    If you live with psoriasis then you know how difficult it can be to plan your day around your flare-ups. When your skin becomes inflamed with itchy, scaly plaques, you may not feel like leaving the house.

    Luckily, you have options, one of which may be as simple as diagnosing and treating a vitamin D deficiency. At Skinworks Dermatology, with three New York City locations, dermatologist Javier Zelaya, MD, and our team are dedicated to caring for your skin.

    If psoriasis is affecting your quality of life, dont hesitate to contact Dr. Zelaya. He can help you determine what might be causing your psoriasis or making your symptoms worse. One of those factors could be a vitamin D deficiency.

    How Does Vitamin D Treat Psoriasis

    The vitamin D analog calcipotriol is widely and successfully used in the topical treatment of psoriasis .

    Synthetic vitamin D is considered safe for most patients, including children. It clears psoriasis in some patients, including patients who have scalp psoriasis. Most people notice an improvement after using it for two weeks. If a patient needs stronger medicine, synthetic vitamin D can be safely combined with a strong corticosteroid.

    Mild to moderate psoriasis is often successfully.

    It also contains vitamin D, which slows down the growth of skin cells before plaques can form. Its not meant to be used on the face.

    Abruptly stopping steroid treatment can cause worsening of psoriasis.

    most commonly used vitamin D3 analog for psoriasis. However, such vitamin D analogs are not effective alone for treatment.

    During treatment with vitamin D analogs, the psoriatic lesions demonstrated significant reduction in number as compared to the number of lesions present before.

    France: A new study by Laetitia Penso and colleagues reported that the risk of serious infections is increased in new users.

    Typically, the best natural treatment for psoriasis is exposure to sunlight, in order to optimize your vitamin D levels. Vitamin D can also be.

    Take a look: 1. Vitamin D Vitamin D helps regulate T-cells. Vitamin D acts as a hormone in the body. In particular, it acts like cortisol,

    Treating plaque psoriasis with both topical corticosteroids and vitamin D medications may.

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