Thursday, November 30, 2023

Skin Disease Similar To Psoriasis

Acne: Blocked Pores That Lead To Pimples

Psoriasis: treatment options related issues

Some forms of psoriasis appear as pus-filled blisters that may be confused with pimples. Pustular psoriasis forms white blisters that are filled with pus and surrounded by red skin. Far more common than psoriasis, acne also causes a pus-filled pimple eruption. However unlike psoriasis acne is caused by excess oil, blocked pores, and bacteria. Acne is common in teens and young adults and occurs on the face, neck, back, or chest. Pustular psoriasis is usually seen in adults and can occur anywhere on the body, but less likely on the face.

There Can Be Overlap Between Eczema And Psoriasis

  • Still in some children, its hard to tell the difference. In this case, a dermatologist might diagnose the child with psoriasiform dermatitis.

  • Sometimes, a child has both eczema and psoriasis, so there can be some overlap.

  • A dermatologist, however, will generally be able to differentiate between these two relatively common skin disorders.

All content solely developed by the American Academy of Dermatology

Can Psoriasis Affect Only My Nails

In some cases, psoriasis may involve only the fingernails and toenails, although more commonly, nail symptoms will accompany psoriasis and arthritis symptoms. The appearance of the nails may be altered, and affected nails may have small pinpoint pits or large yellow-colored separations on the nail plate called “oil spots.” Nail psoriasis can be hard to treat but may respond to medications taken for psoriasis or psoriatic arthritis. Treatments include topical steroids applied to the cuticle, steroid injections at the cuticle, or oral medications.

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Psoriasis Susceptibility Genes Identified By Gwass

Advances in high-throughput genotyping technologies and the completion of the genome-wide database of common genetic sequence variation have paved the way to the identification of a number of psoriasis susceptibility genes by means of GWAS and subsequent meta-analysis . Collectively, these studies identified 36 independent psoriasis-associated regions within individuals of European ancestry , plus five more uniquely associated in the Chinese population .

Preparation And Characterization Of Act


The ACT-Dex conjugate was synthesized by an EDC/DMAP-catalyzed esterification between ACT and dextran . 1H NMR was performed to confirm the structure of the resultant ACT-Dex . All characteristic peaks were well assigned, indicating the successful conjugation of ACT to dextran. It was quite challenging to quantify the amount of ACT in this conjugate by NMR integrations because the ACT-Dex conjugate formed self-assembled structures even in organic solvents. The reason can be ascribed to the formation of hydrogen bonds and the unfavorable solubility of both dextran and ACT moieties in organic solvents after esterification. Since the UV-vis absorption of ACT at 360 nm displayed a linear relationship with the concentration , UV-vis spectroscopy was employed to confirm and quantify the amount of ACT in ACT-Dex. The ACT content in ACT-Dex was calculated to be 52.9%, indicating that 1.79 repeat units of dextran on average were conjugated with one molecule of ACT.

FIGURE 1. Synthesis, characterization of ACT-Dex NPs. Schematic illustration of the synthesis of ACT-Dex conjugate and preparation of ACT-Dex NPs. Hydrodynamic diameter and representative TEM image of ACT-Dex NPs. In vitro ACT release from the NPs. Data were presented as mean ± standard deviation of three independent experiments.

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Plaque Psoriasis: Red Bumps And Silvery Scales

Plaque psoriasis is the most common form of the chronic skin condition, affecting about 80 percent of people with psoriasis. Usually starting as small red bumps on the skin, plaque psoriasis develops into red patches with a silvery, scaly coating these raised patches are called plaques. Plaques usually show up on elbows, knees, and the lower back, and they can last for months or even years without treatment.

In Vivo Effect Studies Of Act

2.8.1 IMQ-Induced Psoriasis-like Murine Model and In Vivo Treatment

Wild-type Balb/c female mice were provided by the Institute of Laboratory Animal Science . The animal experiments were approved by the Animal Experimentation Ethics Committee of HUST and performed according to the protocols from the Hubei Provincial Animal Care and Use Committee. Mice received daily topical treatment of IMQ on their back skin for 6 consecutive days to fabricate the psoriasis model. 2 hours after IMQ cream application, mice were treated with an intraperitoneal injection of Dex , ACT , ACT-Dex NPs , or PBS for 6 consecutive days.

2.8.2 Psoriasis-like Lesion Evaluation

Disease severity was assessed with a clinical scoring system based on the Psoriasis Area and Severity Index scores as previously reported. The severity of inflammation was reflected by the cumulative score of scaling, erythema, and thickness . The back skinfold thickness was measured daily in triplicate using a vernier caliper before treatment. Data were presented as the percentage change from baseline.

2.8.3 Histological and Immunohistochemical Analysis
2.8.4 Body Weight and Spleen Weight

Body weights of the mice were recorded on day 1st and day 7th when they were sacrificed. Their spleens were then removed and weighed. Spleen index was calculated by the weight ratio between spleen and body.

2.8.5 Hematological and Organ Toxicity Studies

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How Is Psoriasis Diagnosed And Treated

Psoriasis often has a typical appearance that a primary care doctor can recognize, but it can be confused with other skin diseases , so a dermatologist is often the best doctor to diagnose it. The treatment of psoriasis usually depends on how much skin is affected, how bad the disease is , or the location . Treatments range from creams and ointments applied to the affected areas to ultraviolet light therapy to drugs . Many people who have psoriasis also have serious health conditions such as diabetes, heart disease, and depression. Some people with psoriasis also have an inflammatory condition which affects their joints, called psoriatic arthritis.

Psoriatic arthritis has many of the same symptoms as other types of arthritis, so a rheumatologist is often the best doctor to diagnose it. The treatment of psoriatic arthritis usually involves the use of drugs .

Psoriatic disease may be treated with drugs or a combination of drugs and creams or ointments.

Measurement Of Stat3 Expression In Vitro

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Western blot analysis was performed to determine STAT3 expression in vitro. HaCaT cells were treated with PBS, Dextran , ACT or ACT-Dex NPs for 12 h. Subsequently, the cells were further stimulated using recombinant IL-22 for an additional 1 h, and the cell lysate was prepared. After electrophoresis, proteins were electroeluted onto a polyvinylidenedifluoride membrane . Antibodies: anti-pSTAT3 , STAT3 , and anti-actin . For the visualization of the immunoreactive proteins, an enhanced chemiluminescence assay kit and a chemiluminescence imaging system were used.

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Superior Amelioration Of Psoriasis

FIGURE 2. Therapeutic effects of different treatments. Psoriasis area and severity index scores of skin lesions in IMQ-induced psoriatic mice following different treatments. Representative photographs and H& E staining of the back skin derived from mice in different groups on day 7th. Skinfold thickness and epidermal thickness of the back skin derived from mice in different groups. Data were presented as mean ± standard deviation of three independent experiments. . The scale bar in the bottom right figure of applies to the others.

Generally, the keratinocytes are excessively proliferated in psoriatic skin lesions, and the inflammatory cascade in lesions is critically dependent on keratinocytes. We thus analyzed the expression of Ki67, a marker of the proliferation of keratinocytes, in the epidermis by Ki67 IHC staining. We found a remarkable Ki67 upregulation in the PBS and Dex groups, whereas it was slightly inhibited in the ACT group and profoundly inhibited by the ACT-Dex NPs . These findings suggested that ACT-Dex NPs were more efficient in ameliorating psoriasis-like murine skin disease than neat ACT drugs at an equivalent low dosage.

FIGURE 3. In vivo Ki67 expression in different treatments. Representative Ki67 IHC staining images of the skin sections in theIMQ-induced psoriatic mice following different treatments. The number of Ki67 + cells per square millimeter. . The scale bar in the bottom right figure of applies to the others.

What Else Should I Ask My Healthcare Provider

If you have psoriasis, ask your healthcare provider:

  • How can I prevent outbreaks and control symptoms?
  • What medication will work best for me?
  • What else should I do to improve symptoms?
  • What are my options if creams dont work?
  • Will psoriasis ever go away?

A note from Cleveland Clinic

Psoriasis, an itchy skin condition, can come and go throughout your life. Its related to an overactive immune response and is not contagious. If you have skin changes that arent going away, talk to your healthcare provider. There is no cure for psoriasis, but psoriasis treatments can improve symptoms. Your provider may prescribe a special cream or moisturizer or medications. Other therapies are available if creams or medicines dont work. Maintaining your overall health will also help improve symptoms.

Last reviewed by a Cleveland Clinic medical professional on 10/17/2020.


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Biomarkers In Psoriatic Arthritis

Studies show that psoriatic arthritis is underdiagnosed in patients with psoriasis vulgaris probably due to the heterogeneity of this condition but also to the lack of systemic biomarkers. Several authors therefore tried to identify biomarkers for psoriatic arthritis which could improve the diagnosis of this disease .

A study performed on 52 patients with psoriasis and 26 controls aimed to identify serum biomarkers for psoriatic arthritis and psoriasis. The authors found higher levels of highly sensitive CRP , osteoprotegerin , and MMP-3 in patients with psoriasis and psoriatic arthritis as compared to patients with psoriasis alone and concluded that these could be biomarkers for psoriatic arthritis in patients with psoriasis . hsCRP is a sensitive marker of inflammation. OPG is a marker of periostitis, and new bone formation and MMP-3 is an enzyme with a role in bone and cartilage destruction .

Other authors showed that the levels of S-calprotectin and hsCRP are significantly higher in patients with psoriatic arthritis than in healthy controls. S-Calprotrectin seems to reflect the better burden of the joint disease than hsCRP and is a potential biomarker for psoriatic arthritis .

Cytokine levels were also measured in patients with psoriatic arthritis. The levels of IL-1 receptor antagonists are correlated with the severity of joint disease . Il-6 is also significantly higher in patients with psoriasis and psoriatic arthritis than patients with psoriasis alone .

How Psoriasis Is Diagnosed

Skin Disease: Body Diseases Your Skin Reveals

A GP can often diagnose psoriasis based on the appearance of your skin.

In rare cases, a small sample of skin called a biopsy will be sent to the laboratory for examination under a microscope.

This determines the exact type of psoriasis and rules out other skin disorders, such as seborrhoeic dermatitis, lichen planus, lichen simplex and pityriasis rosea.

You may be referred to a specialist in diagnosing and treating skin conditions if your doctor is uncertain about your diagnosis, or if your condition is severe.

If your doctor suspects you have psoriatic arthritis, which is sometimes a complication of psoriasis, you may be referred to a doctor who specialises in arthritis .

You may have blood tests to rule out other conditions, such as rheumatoid arthritis, and X-rays of the affected joints may be taken.

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Heat Rash: Sweating That Leads To Bumpy Red Skin

Inverse psoriasis is a type of psoriasis that forms in the armpits and skin folds under breasts or in groin areas, making the skin red and shiny. Sweating makes this type of psoriasis worse. Heat rash also makes your skin red and forms in skin folds of the groin, breasts, and armpits. Heat rash occurs in hot, humid conditions. Sweating can cause your pores to get blocked and result in a bumpy, red skin rash that stings. Heat rash is more common in newborns, but can also affect older children and adults.

Are There Complications Of Psoriasis

In some people, psoriasis causes more than itchiness and red skin. It can lead to swollen joints and arthritis. If you have psoriasis, you may be at higher risk of:

  • Use medicated shampoo for scales on your scalp.

Other steps you should take to stay as healthy as possible:

  • Talk to your healthcare provider about lowering your risk for related conditions, such as heart disease, depression and diabetes.
  • Lower your stress with meditation, exercise or seeing a mental health professional.

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Measles: A Facial Rash That Can Cover The Body

Like guttate psoriasis, measles also follow symptoms of an upper respiratory infection in children and cause a skin rash of small, red spots. However, the measles skin rash usually starts on the face and spreads down to cover the body and is accompanied by fever, cough, and a runny nose. Measles rash is also flat, while the rash of psoriasis is typically raised. Measles is caused by a virus and is contagious, though the measles vaccination has made this a rare disease in the United States.

What Causes Psoriasis And Eczema

Psoriasis: Under the Skin

Causes of psoriasis

We dont know the exact cause of psoriasis, but we do know that its a type of autoimmune disease, meaning that an overactive immune system is involved. The main symptom of psoriasis is thick skin plaques, caused by skin growing too quickly.

Your genes and family history can play a role in whether or not you develop psoriasis. About 40% of people with psoriasis have a family member with psoriasis. And if one parent has psoriasis, a child has about a 30% chance of having it.

Then, there are triggers that can worsen psoriasis symptoms. While each person is different, common triggers for psoriasis include stress and certain infections, like strep throat. Some medications can also act like triggers. Examples include lithium, propranolol , and hydroxychloroquine .

Causes of eczema

The word eczema actually refers to a group of skin conditions that can cause your skin to become red and itchy. Common types of eczema include atopic dermatitis, seborrheic dermatitis, and contact dermatitis.

Often, when people talk about eczema, theyre referring to atopic dermatitis, the most common type of eczema. In fact, over 18 million Americans have atopic dermatitis, 13% of which are children. For this article, well stick to talking about atopic dermatitis.

Like psoriasis, eczema can worsen with triggers. These can include dry skin, stress, and different irritants, like wool and perfumes. Everyday allergens like pollen and dust mites can also be triggers.

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What Are Other Types Of Psoriasis

Plaque psoriasis is the most common type. About 80% to 90% of people with psoriasis have plaque psoriasis.

Other, less common types of psoriasis include:

  • Inverse psoriasis appears in skin folds. It may look like thin pink plaques without scale.
  • Guttate psoriasis may appear after a sore throat caused by a streptococcal infection. It looks like small, red, drop-shaped scaly spots in children and young adults.
  • Pustular psoriasis has small, pus-filled bumps on top of the red patches or plaques.
  • Sebopsoriasis typically appears on the face and scalp as red bumps and plaques with greasy yellow scale. This type is a cross between psoriasis and seborrheic dermatitis.

Can You Treat Eczema And Psoriasis The Same Way

Some of the medications that are used to treat psoriasis may help treat eczema and vice versa. This doesnt necessarily mean that theres a one-size-fits-all treatment plan for both conditions though. A dermatologist can help you find a treatment plan that will work best for you based on your individual symptoms and medical history.

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The Five Types Of Psoriasis

  • Plaque psoriasis: As the most common type of psoriasis, this condition appears as patches of thick, scaly and silvery plaques on the skin.
  • Guttate psoriasis: A large-scale rash with small, reddish bumps that can often be linked to streptococcal or a bacterial infection.
  • Inverse psoriasis: Dry, red, scaly patches form in the folds of the skinsuch as armpits.
  • Pustular psoriasis: Puss-filled blisters form on the skin.
  • Erythrodermic psoriasis: An aggressive form of psoriasis that causes widespread peeling, burning, fever and inflammation.

Medical Treatment Topical Agents

Stress as an Influencing Factor in Psoriasis

The first line of treatment for psoriasis includes topical medications applied to your skin. The main topical treatments are corticosteroids , vitamin D-3 derivatives, coal tar, anthralin, and retinoids. These drugs may lose potency over time, so often they are rotated or combined. Ask your doctor before combining medications, as some drugs should not be combined.

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Skin Diseases Similar To Psoriasis

Psoriasis is a chronic skin condition characterized by thick, raised red patches.

At a basic level, psoriasis is a disorder of the immune system.

These products can mask redness and psoriasis plaques. They can irritate the skin, however, and shouldnt be used on open sores, cuts or unhealed lesions. Preparing for your appointment. Youll likely first see your family doctor or a general practitioner. In some cases, you may be referred directly to a specialist in skin diseases .

It has been used to treat various medical conditions like muscle pain, migraine and even stress. Just recently, however, it has been proven that acupuncture can also help ease skin problems like acne,

Topical Drug Delivery Market research report studies latest Topical Drug Delivery business aspects market size, share, trends, growth, business overview and Topical Drug Delivery business.

Psoriasis and atopic dermatitis are chronic skin diseases that greatly affect.

A total of 48 and 91 patients suffering from skin diseases and work-related stress, respectively, were included in the.

Learn psoriasis causes, treatment, medication, and types: scalp, vulgaris, guttate, inverse, and pustular. Red dry flakes, silvery-white skin scales, and plaques of raised skin are common symptoms and signs. Read how diet impacts psoriasis, whether its contagious, and the outlook for cure.

Eczema and psoriasis are two distinct skin diseases that may require.

This is because many skin conditions can seem similar in.

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