Tuesday, July 9, 2024

Psoriasis Flare Up On Humira

Infusion Therapy Treatment For Psoriasis

Psoriasis and My first Week on Humira

Psoriasis is a common, chronic skin disease that causes itchy, scaly, red patches to develop throughout the body, often appearing on the scalp, elbows, and knees. Though the cause of psoriasis is not totally understood at present, the immune system and genetics both contribute to its onset. People with psoriasis generally experience flare-ups due to triggers such as stress, skin injury, medications, excessive consumption of alcohol, and infections. While psoriasis can make life very uncomfortable, infusion therapy can disrupt the inflammation cycle of the disease and provide a high degree of relief.

Fingernail Psoriasis Study Design12913

A Phase 3, randomized, double-blind study evaluated adult subjects with moderate to severe fingernail psoriasis who also had moderate to severe chronic plaque psoriasis.1,2

BSA=body surface area EOW=every other week mNAPSI=modified Nail Psoriasis Severity Index

PGA-F=Physicians Global Assessment of Fingernail Psoriasis PGA-S=Physicians Global Assessment of Skin Psoriasis.

Key inclusion criteria were adult subjects with2:

  • Moderate to severe chronic plaque psoriasis with disease duration of at least 6 months and psoriasis in at least one fingernail
  • Fingernail involvement moderate as measured by 5-point PGA-F scale
  • mNAPSI score of target fingernail 8
  • BSA 10%, or 5% BSA with a total mNAPSI score for all fingernails 20

Primary endpoint was proportion of subjects achieving PGA-F of 0 or 1 and at least 2-grade improvement from baseline at Week 26.

Key secondary endpoint was proportion of subjects achieving 75% improvement from baseline in mNAPSI at Week 26.


Does Humira Cause Hair Loss Or Weight Gain

In very rare cases, Humira may cause some hair loss.

Unexplained weight loss or weight gain, though, is not directly caused by Humira. However, its active ingredient increases the risk of lymphoma, leukemia, and other cancers, many of which are characterized by loss of appetite and involuntary weight loss. Talk to a doctor immediately if you notice weight loss, decreased appetite, or getting full on a small amount of food while taking Humira.

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Symptoms Of Psoriatic Arthritis

The severity of the condition can vary considerably from person to person. Some people may have severe problems affecting many joints, whereas others may only notice mild symptoms in 1 or 2 joints.

There may be times when your symptoms improve and periods when they get worse .

Relapses can be very difficult to predict, but can often be managed with medicine when they do occur.

These 12 Medications Can Worsen Your Psoriasis

psoriasis flare ups in fluctuating weather dr health clinic Dr. Health Clinic” alt=”PSORIASIS FLARE UPS IN FLUCTUATING WEATHER > Dr. Health Clinic”>

Here, well review the main medications that have been associated with worsening psoriasis. Most of these drugs can make existing psoriasis worse and cause you to develop new psoriasis lesions.

Well start with the more common medications and then discuss some of the newer, less common ones. One class of medications called corticosteroids is discussed at the end. Unlike the others, it can trigger psoriasis when you stop rather than start taking it.

Keep in mind that these medications dont cause psoriasis in everyone, and there are other medications that can trigger psoriasis not included on this list.

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If Your Doctor Has Recommended Infusion Therapy Let Infusion Associates Help You

At Infusion Associates, we provide medically-prescribed infusion therapy for patients with chronic conditions in a welcoming and friendly environment. Our team of healthcare professionals is fully committed to making the experience as comfortable as possible for you or your patients. We always inform patients of any potential side effects and answer all their questions before starting treatment. In addition, we have a Registered Pharmacist or Medical Provider on-site to make the process as seamless as possible.

If you would like to refer a patient to us or want to inquire about the treatments we offer, you can contact us by calling us at or filling out this form.

Possible Causes For Psoriasis Remission

The goal of psoriasis treatment is to reduce the symptoms and hopefully end the flare. If treatments are successful, psoriasis may go into remission.

Even without treatment, psoriasis may disappear. Spontaneous remission, or remission that occurs without treatment, is also possible. In that case, its likely your immune system turned off its attack on your body. This allows the symptoms to fade.

This doesnt mean that you wont ever have another flare. Watch for symptoms of psoriasis so that you can begin treating them if they reappear.

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When To Talk To Doc

In general, if this is the first time youre noticing red, flaky lips, give your doc a call. Theyll be able to diagnose whether its a psoriasis rash. Its also important to reach out if your symptoms are getting worse.

If you start to notice symptoms such as pain, swelling, tenderness, stiff muscles and joints, or a noticeable change in the appearance of your nails, says Markowitz, call your doctor.

Never try a new treatment including OTC ones without checking with your doctor either.

Who Humira Is Prescribed For

Psoriasis Update – Graphic Images | Humira Diaries

Humira is not for everyone with plaque psoriasis. Your doctor may suggest it as a treatment for you if:

  • youre an adult with chronic plaque psoriasis, and
  • your plaque psoriasis is moderate to severe, and
  • youre eligible for or systemic therapy to treat plaque psoriasis, and
  • your plaque psoriasis would benefit more from Humira than it would from other systemic therapies, or
  • you cannot use other systemic therapies

Your doctor can give you more information about phototherapy and other systemic therapies. Theyll guide you on which treatments are likely to work best for you.

Humira works to treat plaque psoriasis by decreasing certain actions in your immune system.

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Could It Be Something Else

The short answer: Yes.

Psoriasis on lips is pretty rare. Here are some more common things that can cause a rash on your lips:

  • Eczema. This can also cause redness, drying and scaling of one or both lips. It can also affect the skin inside and around your mouth.
  • Chapped lips. Its common and can cause cracking, but chapped lips will usually get better with simple treatments. Applying lip balm, using a humidifier, and drinking more water should do the trick.
  • Cheilitis. A condition that causes red, dry, scaling, and itchy lips. Theres a few different types of cheilitis but they all involve inflammation and could reoccur even after theyve cleared up.
  • Cold sores. These usually begin with pain or burning first. Then youll see fluid-filled blisters emerge along the lip line.

Here are a few examples of what psoriasis and other causes may look like on lips.

Remember, its always best to see a doctor for a diagnosis. That way youll know what kinds of treatments will work best for you.

Here Are The Main Clues A Psoriatic Arthritis Flare Is Coming And How To Make It Go Away More Quickly

You could fry an egg on it is how one patient with psoriatic arthritis described her skin flare in a 2015 study. Affecting up to one-third of people with the inflammatory skin condition psoriasis, psoriatic arthritis is a double-whammy that has the hallmarks of both psoriasis and inflammatory arthritis . These painful symptoms may increase at certain times, called flares or flare-ups.

Science hasnt come as far in understanding psoriatic arthritis flares as it has with other types of inflammatory arthritis, such as rheumatoid arthritis.

Flares are one of the toughest things to pin down because theres no real set definition a flare, which could mean different things to different people, says Elaine Husni, MD, MPH, a rheumatologist at Cleveland Clinic. Because of this, it can be hard for patients especially those recently diagnosed with psoriatic arthritis to know when its happening.

The line between an official flare-up and the normal waxing and waning of symptoms is definitely a difficult and confusing determination for many patients to make, says occupational therapist Cheryl Crow, MOT, OTR/L, an adjunct faculty member of the Occupational Therapy Assistant program at Lake Washington Institute of Technology and an American Occupational Therapy Association spokesperson. At the most basic level, a flare-up is a period of acutely worsening symptoms however, for psoriatic arthritis, the symptoms may differ from patient to patient.

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Research And Statistics: Who Has Psoriasis

According to the National Psoriasis Foundation, about 7.5 million people in the United States have psoriasis. Most are white, but the skin disease also affects Black, Latino, and Asian Americans as well as Native Americans and Pacific Islanders.

The disease occurs about equally among men and women. According to the National Institutes of Health , it is more common in adults, and you are at a greater risk if someone in your family has it. A study published in September 2016 in the journal PLoS One concluded that interactions between particular genes as well as genetic and environmental factors play an important role in the diseases development.

People with psoriasis generally see their first symptoms between ages 15 and 30, although developing the disease between 50 and 60 years of age is also common.

The biggest factor for determining prognosis is the amount of disease someone has, says Michael P. Heffernan, MD, a dermatologist at the San Luis Dermatology and Laser Clinic in San Luis Obispo, California.

Common Side Effects Of Humira

Best Home Remedies for Psoriasis Flare

Humira suppresses the immune system, so infections and malignancies are common as well as potentially serious side effects. Also, as a subcutaneous injection, Humira produces injection site reactions in about 1 in 5 patients. The most common side effects of Humira are:

  • Injection site reactions
  • Upper respiratory infections

Read Also: How Do You Treat Plaque Psoriasis

Pustular Psoriasis On The Palms And Soles

Some people — mostly adults who smoke — get pustular psoriasis on their palms and soles. Known as palmoplantar pustulosis , it can erupt over months or years. It may also cause painful cracks, redness, and scales. It can be more stubborn to treat than other types of hand and foot psoriasis, but the same methods are used. Learn five ways you can treat deep cracks and protect your skin.

Psoriasis Triggers And Avoiding Flare

Psoriasis is common, affecting about 125 million people worldwide. While its not entirely understood, medical experts believe psoriasis is an immune response. The immune system causes skin cells to regenerate quicker than usual. There is no cure, but there are ways to avoid psoriasis triggers and avoid symptom flare-ups. Weve gathered some common triggers and treatment options that may help control symptoms.

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When To Get Medical Advice

See a GP if you have persistent pain, swelling or stiffness in your joints even if you have not been diagnosed with psoriasis.

If you’ve been diagnosed with psoriasis, you should have check-ups at least once a year to monitor your condition. Make sure you let the doctor know if you’re experiencing any problems with your joints.

Before Stopping Psoriasis Treatment Talk With Your Dermatologist

My Psoriasis and Humira UPDATE!

Because psoriasis is a lifelong disease, its understandable that you may want to stop treatment at some point. Alwaystalk with your dermatologist before you stop treatment.

Some treatments can be stopped immediately. Others need to be discontinued slowly to prevent psoriasis from worsening .

When psoriasis rebounds, it may become a more serious type of psoriasis. A person who had plaque psoriasis may suddenly have pustular psoriasis or erythrodermic psoriasis.

The best way to prevent a rebound is to talk with your dermatologist. Your dermatologist can tell you whether you can stop the treatment abruptly or slowly. Sometimes, the best approach is to gradually switch to another treatment.

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Can Using Humira Cause Weight Gain Or Weight Loss

Neither weight gain nor weight loss were reported as side effects in people taking Humira in clinical trials.

But unintended weight loss may be a symptom of other side effects of Humira, such as an infection. And sudden weight gain may be a symptom of heart failure, which is a rare but serious side effect of taking Humira.

If youre concerned about your weight while taking Humira, talk with your doctor. They can discuss ways to help maintain a weight thats healthy for you. If you notice unintended, sudden changes in your weight, call your doctor. This may be a symptom of more serious side effects of Humira.

Path Of Continuous Ew Population For Pioneer I And Ii Integrated Analysis Of Flare Occurrence 1

Patients treated with HUMIRA received continuous HUMIRA 40 mg weekly over 36 weeks

  • HUMIRA40 mg EW
  • Flare defined as 25% increase in AN count and an absolute increase of 2 relative to baseline.1,2
  • Included 11 ADAew/ew patients who escaped period B early due to loss of response or worsening or absence of improvement and continued ADAew treatment in the OLE.8
PIONEER I control=placebo PIONEER II control=placebo +/- antibiotic

LOR: Loss of response

WOAI: Worsening or absence of improvement

aStratified by baseline Hurley Stage II vs III and baseline concomitant antibiotic use .

b160 mg week 0 80 mg week 2 40 mg from week 4.

*ADAew/ew population, defined as patients randomized to ADAew in Period A and re-randomized to ADAew in Period B due to loss of response or worsening or absence of improvement and continued ADAew treatment in the OLE.


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Pregnancy And Breastfeeding While Taking Humira

You and your doctor should decide whether Humira is the right choice for you to take while youre pregnant or breastfeeding.

It isnt known for sure whether Humira is safe to take while pregnant or breastfeeding. In people who have taken the drug while breastfeeding, no side effects have been reported.

If you have questions about taking Humira while pregnant or breastfeeding, talk with your doctor.

Psoriasis: A Chronic Skin Condition Characterised By Thick Red Patches With Flaky Silvery Scales

I noticed this a couple of days ago on my upper neck/back ...

In Singapore, an estimated 40,000 people suffer from the disease, according to the Psoriasis Association of Singapore. Psoriasis can affect men, women and children at any age, though it has been found to be more common between the ages of 15 to 45.

Psoriasis can be mistaken for dandruff when occurring on the scalp. Besides the scalp, psoriasis can affect any part of the skin, in particular the knees, elbows, hands, feet and lower back. In severe cases, the patches can be accompanied by painful joint swelling as well as joint disfigurement.

Psoriasis patches can range from minor dandruff-like scaling to major eruptions covering large areas of skin, says Associate Professor Pang Shiu Ming, Senior Consultant from the Department of Dermatology at Singapore General Hospital , a member of the SingHealth group.

In its severe form, psoriasis can be incapacitating, significantly affecting the patients quality of life. On rare occasions, very severe psoriasis can be life-threatening.

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Toxicity Or Side Effects Develop

Both conventional systemic drugs and biologics can have severe side effects.

Liver toxicity has been associated with long-term use of the conventional drug methotrexate, while kidney toxicity has been associated with long-term use of cyclosporine.

Because of this risk, conventional systemic drugs like methotrexate, oral retinoids, and cyclosporine are typically only given for a short time.

Biologics also have side effects. Because they affect the immune system, they can increase the risk of infections, such as tuberculosis and pneumonia, as well as staph and fungal infections.

If your healthcare provider finds that any of these toxicities or serious side effects occur, youll probably need to change treatments.

What Will Happen If I Stop Treating My Psoriasis

One of three things happens when you stop treatment:

  • You may stay clear and have no psoriasis symptoms .

  • Your psoriasis may return, looking and feeling much like it did before .

  • The psoriasis may return and be worse than before .

  • What happens often depends on the medication you were using when you stopped, how well you manage your psoriasis triggers, and your medical history.

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    How Does Humira Compare To Enbrel

    Humira and Enbrel are very similar drugs. But how people respond to either drug can vary.

    Both medications belong to the same class of drugs,* called tumor necrosis factor blockers. Theyre both approved to treat plaque psoriasis, and both are given by subcutaneous injection. Humira is injected every other week. Enbrel is injected once per week.

    Humira and Enbrel can cause many of the same side effects. In a clinical study that compared the two drugs, Humira was shown to cause worse injection site side effects than Enbrel. These effects included stinging and burning at the injection site.

    However, a newer formulation of Humira may cause injection site reactions less often. Its called Humira Citrate-free. You and your doctor can discuss your treatment options and decide which drug is best for you.

    * A drug class is a group of medications that work in a similar way.

    Employ Some Life Hacks

    My battle with Psoriasis. (Humira Shot)

    Crow also advises taking shortcuts that can make living with PsA flares easier. These life hacks can help minimize fatigue or joint pain, she says. If your joints hurt, you can change the stuff you are using in your daily life for example, if your hands hurt, you can use a wide-grip fork while eating. You can also change how you interact with stuff, such as choosing to have grocery delivery rather than exerting the energy required to go to the store and bag all the items yourself.

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    Look For More Symptoms

    I have named a few red flags of a flare-up, but there are many others, as well. You may have joint pain in your jaw, elbow, or shoulders. You may experience digestive issues, anxiety, or any number of symptoms. Its important to always be cognizant of your body and take the time to check in. If you can get ahead of a flare before it gets worse, youll be better off in the long run! Be prepared and get a game plan in place for if you run into any of these 10 red flags.

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